In men, depot mixtures of testosterone esters can be given intramuscularly in doses of 250ΓÇô750mg every two to four weeks. The dose varies widely from 125mg every two weeks to 500mg every four weeks. Occasionally polycythaemia can develop on testosterone replacement therapy and the haemaglobin concentration should be monitored during treatment. A safe oral testosterone preparation (testosterone undecanoate 40-80mg three times daily) is also available. Strength, vigour, libido and potency are all improved.If spermatogenesis is required, treatment may be given either with human menopausal gonadotrophin (such as menotrophin) or with GnRH delivered intermittently with a pump; spermatogenesis occurs after a minimum of three months' treatment.
